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危险化学品介绍
氟乙酸甲酯虽然不属于《危险化学品名录》(2002版)中的危险化学品，但属于剧毒化工品，具有易燃特性，刺激人的眼睛、呼吸系统和皮肤，接触不慎有致命危险，出现过致人死亡的极端案例。避免人体直接接触，接触时应穿戴适当的防护服。氟乙酸甲酯是一个重要的含氟化合物，在染料、医药、农药等工业领域有着广泛的用途和发展前景。在医药工业氟乙酸酯是一个重要的医药中间体，是制备氟代嘧啶类抗肿瘤药物和氟喹诺酸类抗菌药物的起始原料，属于剧毒化工品，接触不慎有致命危险。
氟乙酸甲酯毒性：
|
编号
|
毒性类型
|
测试方法
|
测试对象
|
使用剂量
|
毒性作用
|
|
1
|
acute
|
Oral
|
Human - man
|
650 ug/kg
|
1.胃肠道毒性Gastrointestinal - nausea or vomiting
|
|
2
|
acute
|
Oral
|
Rodent - rat
|
3500 ug/kg
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
2.心脏毒性Cardiac - arrhythmias (including changes in conduction) 3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea |
|
3
|
acute
|
Inhalation
|
Rodent - rat
|
300 mg/m3/10M
|
1.Details of toxic effects not reported other than lethal dose value
|
|
4
|
acute
|
Subcutaneous
|
Rodent - rat
|
5 mg/kg
|
1.行为毒性Behavioral - tremor
2.行为毒性Behavioral - convulsions or effect on seizure threshold 3.行为毒性Behavioral - excitement |
|
5
|
acute
|
Intramuscular
|
Rodent - rat
|
2500 ug/kg
|
1.Details of toxic effects not reported other than lethal dose value
|
|
6
|
acute
|
Oral
|
Rodent - mouse
|
5 mg/kg
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
2.心脏毒性Cardiac - arrhythmias (including changes in conduction) 3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea |
|
7
|
acute
|
Inhalation
|
Rodent - mouse
|
3200 mg/m3/10M
|
1.Details of toxic effects not reported other than lethal dose value
|
|
8
|
acute
|
Intraperitoneal
|
Rodent - mouse
|
7500 ug/kg
|
1.Details of toxic effects not reported other than lethal dose value
|
|
9
|
acute
|
Subcutaneous
|
Rodent - mouse
|
5 mg/kg
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
2.心脏毒性Cardiac - arrhythmias (including changes in conduction) 3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea |
|
10
|
acute
|
Intravenous
|
Rodent - mouse
|
17 mg/kg
|
1.行为毒性Behavioral - coma
2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation 3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands |
|
11
|
acute
|
Parenteral
|
Rodent - mouse
|
6 mg/kg
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
|
|
12
|
acute
|
Oral
|
Mammal - dog
|
100 ug/kg
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
2.心脏毒性Cardiac - arrhythmias (including changes in conduction) 3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea |
|
13
|
acute
|
Inhalation
|
Mammal - dog
|
25 mg/m3/10M
|
1.行为毒性Behavioral - coma
2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation 3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands |
|
14
|
acute
|
Subcutaneous
|
Mammal - dog
|
100 ug/kg
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
2.心脏毒性Cardiac - arrhythmias (including changes in conduction) 3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea |
|
15
|
acute
|
Intravenous
|
Mammal - dog
|
60 ug/kg
|
1.大脑毒性Brain and Coverings - recordings from specific areas of CNS
2.行为毒性Behavioral - convulsions or effect on seizure threshold 3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory depression |
|
16
|
acute
|
Oral
|
Primate - monkey
|
10 mg/kg
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
2.心脏毒性Cardiac - arrhythmias (including changes in conduction) 3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea |
|
17
|
acute
|
Inhalation
|
Primate - monkey
|
800 mg/m3/10M
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
2.心脏毒性Cardiac - arrhythmias (including changes in conduction) 3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea |
|
18
|
acute
|
Subcutaneous
|
Primate - monkey
|
10 mg/kg
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
2.心脏毒性Cardiac - arrhythmias (including changes in conduction) 3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea |
|
19
|
acute
|
Intravenous
|
Primate - monkey
|
4 mg/kg
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
2.行为毒性Behavioral - muscle contraction or spasticity 3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands |
|
20
|
acute
|
Unreported
|
Primate - monkey
|
>50 mg/kg
|
1.Details of toxic effects not reported other than lethal dose value
|
|
21
|
acute
|
Oral
|
Mammal - cat
|
300 ug/kg
|
1.行为毒性Behavioral - coma
2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation 3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands |
|
22
|
acute
|
Inhalation
|
Mammal - cat
|
25 mg/m3/10M
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
2.心脏毒性Cardiac - arrhythmias (including changes in conduction) 3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea |
|
23
|
acute
|
Subcutaneous
|
Mammal - cat
|
300 ug/kg
|
1.行为毒性Behavioral - coma
2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation 3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands |
|
24
|
acute
|
Intravenous
|
Mammal - cat
|
200 ug/kg
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
2.心脏毒性Cardiac - arrhythmias (including changes in conduction) 3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea |
|
25
|
acute
|
Oral
|
Rodent - rabbit
|
500 ug/kg
|
1.行为毒性Behavioral - coma
2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation 3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands |
|
26
|
acute
|
Inhalation
|
Rodent - rabbit
|
25 mg/m3/10M
|
1.Details of toxic effects not reported other than lethal dose value
|
|
27
|
acute
|
Administration onto the skin
|
Rodent - rabbit
|
20 mg/kg
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
|
|
28
|
acute
|
Subcutaneous
|
Rodent - rabbit
|
300 ug/kg
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
2.心脏毒性Cardiac - arrhythmias (including changes in conduction) 3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea |
|
29
|
acute
|
Intravenous
|
Rodent - rabbit
|
200 ug/kg
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
2.心脏毒性Cardiac - arrhythmias (including changes in conduction) |
|
30
|
acute
|
Intraperitoneal
|
Mammal - pig
|
400 ug/kg
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
2.心脏毒性Cardiac - arrhythmias (including changes in conduction) 3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - other changes |
|
31
|
acute
|
Oral
|
Rodent - guinea pig
|
500 ug/kg
|
1.行为毒性Behavioral - coma
2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation 3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands |
|
32
|
acute
|
Inhalation
|
Rodent - guinea pig
|
100 mg/m3/10M
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
|
|
33
|
acute
|
Intraperitoneal
|
Rodent - guinea pig
|
350 ug/kg
|
1.行为毒性Behavioral - tremor
2.行为毒性Behavioral - convulsions or effect on seizure threshold 3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory depression |
|
34
|
acute
|
Subcutaneous
|
Rodent - guinea pig
|
200 ug/kg
|
1.行为毒性Behavioral - coma
2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation 3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands |
|
35
|
acute
|
Intraperitoneal
|
Rodent - hamster
|
2500 ug/kg
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
2.行为毒性Behavioral - excitement 3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea |
|
36
|
acute
|
Intravenous
|
Bird - chicken
|
15 mg/kg
|
1.Details of toxic effects not reported other than lethal dose value
|
|
37
|
acute
|
Subcutaneous
|
Amphibian - frog
|
100 ug/kg
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
2.心脏毒性Cardiac - arrhythmias (including changes in conduction) 3.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea |
|
38
|
acute
|
Unreported
|
Amphibian - frog
|
300 mg/kg
|
1.周围神经毒性Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage)
2.行为毒性Behavioral - convulsions or effect on seizure threshold |
|
39
|
acute
|
Oral
|
Mammal - domestic
|
1 mg/kg
|
1.行为毒性Behavioral - coma
2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation 3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands |
|
40
|
acute
|
Inhalation
|
Mammal - domestic
|
200 mg/m3/10M
|
1.行为毒性Behavioral - coma
2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation 3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands |
|
41
|
acute
|
Subcutaneous
|
Mammal - domestic
|
1 mg/kg
|
1.行为毒性Behavioral - coma
2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation 3.胃肠道毒性Gastrointestinal - changes in structure or function of salivary glands |
|
42
|
acute
|
Intravenous
|
Mammal - domestic
|
600 ug/kg
|
1.心脏毒性Cardiac - arrhythmias (including changes in conduction)
|
|
43
|
acute
|
Intramuscular
|
Mammal - domestic
|
600 ug/kg
|
1.心脏毒性Cardiac - arrhythmias (including changes in conduction)
|
|
44
|
acute
|
Intramuscular
|
Mammal - horse, donkey
|
500 ug/kg
|
1.大脑毒性Brain and Coverings - recordings from specific areas of CNS
2.行为毒性Behavioral - excitement 3.心脏毒性Cardiac - arrhythmias (including changes in conduction) |
|
45
|
Multiple Dose
|
Oral
|
Mammal - dog
|
125 ug/kg/5D-I
|
1.行为毒性Behavioral - convulsions or effect on seizure threshold
2.慢性病相关毒性Related to Chronic Data - death |
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